Workshop 2: January 16, 2026 - Gestational Trophoblastic Disease and Neoplasia: Bridging Histopathology and Genetics

Content for this workshop will become available on January 16, 2026. If you would like to register for all four 2026 January Workshops at the bundled rate, please visit this link.

 

ABSTRACT

​​Pathologists working with obstetrical and gynecologic specimens often encounter a spectrum of trophoblastic proliferations. This workshop will provide the knowledge needed to distinguish entities ranging from hydatidiform moles to placental site and epithelioid trophoblastic tumors. Distinction of these entities from mimics and pathological variants like aneusomy, and twin or chimeric/mosaic moles can be facilitated by understanding trophoblast cell biology in normal human development and the impact of genetic errors, especially those in fertilization. Participants will refine their diagnostic approach to complex trophoblastic lesions and make more informed decisions when selecting ancillary testing.​ 

Target Audience

The education design of this activity addresses the needs of physicians and scientists in the field of pediatric, perinatal and general pathology who are involved in the diagnosis and/or treatment of pediatric patients with pathologic disorders.

Learning Objectives

1. Understand the conceptual framework by which abnormal trophoblastic proliferations are classified. With this framework, learners will develop strategies to classify clinical cases more accurately and efficiently in the WHO schema. 

2. Understand the developmental cell biology of trophoblasts. With this cell biological context, learners will be able to apply immunohistochemical analysis such as p63, CD146 and p57 immunostains as they phenotype abnormal trophoblast proliferations more confidently. 

3. ​​Explore the genetic mechanisms driving gestation trophoblastic disease and neoplasia. Leveraging these genetics insights will provide learners the ability to decide when genetic analysis of ploidy and parental origin is appropriate for diagnosis of trophoblastic disease. 

4. ​​Familiarize the learner with rare variants and mimics of gestational trophoblastic disease, so that they can more readily recognize important pitfalls like twin and chimeric/mosaic moles. 

Course summary
Available credit: 
  • 2.00 ABPATH Lifelong Learning
  • 2.00 AMA PRA Category 1 Credit™
  • 2.00 Participation Credit(s)
Course opens: 
11/17/2025
Course expires: 
01/15/2027
Cost:
$200.00
Part of: 
2026 January Workshops

Available Credit

  • 2.00 ABPATH Lifelong Learning
  • 2.00 AMA PRA Category 1 Credit™
  • 2.00 Participation Credit(s)

Price

Cost:
$200.00
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